Figure 2

Spontaneous and miniature EPSCs evoked in SG neurons at lumbar spinal levels in control and cancer-bearing mice. Representative traces of sEPSCs and mEPSCs in control (A) and cancer-bearing mice (B). Horizontal bars given above the traces show the duration of drug application. Two lower records in A and B: consecutive traces of EPSCs in the absence (right) and presence (left) of TTX shown in an expanded scale in time. The frequency (left) and amplitude (right) of sEPSCs (C) and mEPSCs (D) in SG neurons at spinal levels of L3-5. The amplitudes of sEPSCs and mEPSCs were significantly larger in cancer-bearing than control mice, *P < 0.05 (unpaired t-test). The frequency and amplitude of mEPSCs at different lumber levels (L2-3, n = 5; L4, n = 6; L5, n = 12) in cancer-bearing mice (E). There were no significant differences in the frequency and amplitude of mEPSCs between the three groups. Values represent means ± S.E.M.