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Figure 3 | Molecular Pain

Figure 3

From: Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: A model of myogenic orofacial pain

Figure 3

Effect of local anesthesia on mechanical allodynia and hyperalgesia after TASM ligation. To verify allodynia/hyperalgesia related to tendon injury, local anesthesia was induced in the intraoral site around the TASM or the overlying skin ipsilaterally by lidocaine (4%, 0.05-0.2 ml) in rats receiving tendon ligation and having developed allodynia/hyperalgesia. Compared to saline-treated rats (Saline-Intraoral, n = 5), allodynia/hyperalgesia was significantly attenuated when lidocaine was infiltrated into the TASM site (Lido-Intraoral, n = 5) at 30 min after lidocaine (***, p < 0.001, vs. saline). Local anesthesia of the skin overlying TASM (Lido-Cutaneous, n = 5) did not affect hyperalgesia. Note that some symbols are slightly shifted horizontally for clarity. Error bars represent 95% confidence intervals.

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Molecular Pain

ISSN: 1744-8069

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