Figure 3
Recovery after menthol-induced adaptation in menthol-sensitive/capsaicin-insensitive and menthol-sensitive/capsaicin-sensitive neurons. A) Sample traces show menthol responses and adaptation in a MS/CI neuron and a MS/CS neuron following 5-min menthol application (left panel), recovery for 5 min (middle panel) and 15 min (right panel) in normal bath. The end of 5-min menthol application is indicated. Recovery was tested with short menthol application (10 sec). Menthol concentration was 100 μM for both prolonged and short applications. B) Pooled results show menthol responses (ΔF/F0) in MS/CI (n = 6) and MS/CS neurons (n = 8) at the end of 5-min menthol application, 5 min and 15 min recovery in normal bath. C) Similar to B except menthol responses were expressed as percent of maximum menthol responses observed during 5-min menthol application. Data are mean ± SEM in B and C; *P < 0.05.