Figure 7
Effect of protein kinase inhibitors on menthol responses in MS/CI and MS/CS neurons. A) Responses of MS/CI neurons to prolonged menthol applications (100 μM, 5 min) in control group (red, n = 22) and groups treated with 1 μM BIM (orange, n = 10), 0.5 μM Sta. (green, n = 10), 25 μM KN62 (blue, n = 10), and 25 μM Rp-cAMP (purple, n = 14), P < 0.05. B) Responses of MS/CS neurons to prolonged menthol applications (100 μM, 5 min) in control group (red, n = 18) and groups treated with 1 μM BIM (orange, n = 10), 0.5 μM Sta. (green, n = 10), 25 μM KN62 (blue, n = 10), and 25 μM Rp-cAMP (purple, n = 10). In both A and B, menthol responses were expressed as percent of peak responses. The data for control groups in both A and B are taken from those in Figure 2D. The horizontal bar in each panel indicates duration of 5-min menthol application. Data are mean ± SEM.