Increased food intake with retigabine administration in rats with TMJ inflammation injected with CFA. The food intake in the baseline group was measured in normal rats without CFA injection. Twenty-four hours after CFA injection, the effect of retigabine or morphine as a positive control on food intake was measured, and compared with the vehicle (CFA alone) group. Retigabine enhanced the food intake in dose-dependent manner, as compared with the vehicle. Statistical significance was obtained between the vehicle group and the two groups RTG (7.5 mg/kg, i.p., p < 0.01; and 2.5 mg/kg, i.p., p < 0.05, one-way ANOVA followed by Dunnett's test), and the morphine group (Mor) (5 mg/kg, i.p., p < 0.05, one-way ANOVA followed by Dunnett's test).