Figure 6From: Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats Increased food intake with retigabine administration in rats with TMJ inflammation injected with CFA. The food intake in the baseline group was measured in normal rats without CFA injection. Twenty-four hours after CFA injection, the effect of retigabine or morphine as a positive control on food intake was measured, and compared with the vehicle (CFA alone) group. Retigabine enhanced the food intake in dose-dependent manner, as compared with the vehicle. Statistical significance was obtained between the vehicle group and the two groups RTG (7.5 mg/kg, i.p., p < 0.01; and 2.5 mg/kg, i.p., p < 0.05, one-way ANOVA followed by Dunnett's test), and the morphine group (Mor) (5 mg/kg, i.p., p < 0.05, one-way ANOVA followed by Dunnett's test).Back to article page