Enhanced food intake by retigabine was reversed by the blocker XE991. The food intake in the baseline group represents the value for normal rats without TMJ inflammation. The effect of retigabine or retigabine and XE991 was tested 24 hours after CFA injection. The food intake in the vehicle group indicates the value for rats with TMJ inflammation induced by CFA. Retigabine at a dose of 7.5 mg/kg, i.p. significantly increased the food intake, as compared with the vehicle group (p < 0.005, one-way ANOVA followed by Dunnett's test). Co-injection (i.p.) of XE991 (at 3 mg/kg or 1 mg/kg) with RTG reversed the food intake which had been increased by RTG (7.5 mg/kg, p < 0.05, one-way ANOVA followed by Dunnett's test), as compared with the vehicle group. XE991 at 3 mg/kg had no effect on food intake in rats with TMJ inflammation (p = 0.98), compared with vehicle group. RTG: Retigabine; XE: XE991.