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Figure 5 | Molecular Pain

Figure 5

From: Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain. ketamine, astrocytic inhibitor and pain

Figure 5

Effects of combining ketamine with LAA on SNL-induced mechanical allodynia. PWTs of coadministration group were much higher than that of individual ketamine (100 μg/kg) or LAA (50 nmol) injection at any time points after administration (A). #, $ P < 0.05 compared with that of ketamine 100 μg/kg or LAA 50 nmol, respectively. A', Schematic curves according to A implied that compared with that of individual administration, the anti-allodynia effect of coadministration was more quick, stable and persistent. The analgesic effects of coadministration (100 μg/kg of ketamine and 50 nmol of LAA) compared with that of higher doses of individual ketamine (1000 μg/kg) or LAA (100 nmol), respectively (B). * P < 0.05 compared with that of Ketamine-LAA group. #, $ P < 0.05 compared with that of 1000 μg/kg of ketamine or 100 nmol of LAA, respectively. B', Schematic curves according to B implied that even compared with that of higher doses of individual administration, the anti-allodynia effect of coadministration was still more stable and long-lasting.

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Molecular Pain

ISSN: 1744-8069

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