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Figure 1 | Molecular Pain

Figure 1

From: Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers

Figure 1

Inflammation-induced heat sensitization of TRPV1-negative CPM-fibers. A) Heat thresholds of CPM-fibers were significantly reduced 1 (dark grey bar) and 3 days (medium grey bar) after the injection of CFA and indistinguishable from those in naïve animals (black bar) at day 5 (light grey bar). The combined heat threshold of all time points after inflammation (white bar) was significantly lower than in naïve animals. B) The firing rates of CPM-fibers to noxious heat stimuli (grey symbols) were significantly higher at all time points after inflammation when compared to those from naïve mice (black squares).

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Molecular Pain

ISSN: 1744-8069

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