Skip to main content
Figure 2 | Molecular Pain

Figure 2

From: Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1β maturation

Figure 2

Role of neutrophils and cytokines in caspase-1 mediation of inflammatory hypernociception. (A-B) Wild type and casp1-/- mice received an intraplantar injection of carrageenin or saline. After 3 h, plantar tissue samples were removed and the levels of TNF-α and CXCL1/KC were determined by ELISA. (C) At 3 h after carrageenin injection, the activity of MPO was determined in the mice paw skin of wild type and casp1-/- mice as an index of neutrophil migration. Data are expressed as the mean ± S.E.M. of 5 animals per group. * indicates statistical significance compared to the saline-injected group. P < 0.05, one-way ANOVA followed by the Bonferroni's test.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us