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Figure 4 | Molecular Pain

Figure 4

From: Expression of inwardly rectifying potassium channels by an inducible adenoviral vector reduced the neuronal hyperexcitability and hyperalgesia produced by chronic compression of the spinal ganglion

Figure 4

Comparison of electrophysiological properties of DRG neurons after gene transfer and chronic compression. Comparisons were made among the parameters of recordings obtained in vivo from DRG neurons infected with AdEGI (the control vector) or AdKir (vector expressing Kir current) in rats with or without CCD surgery. Similar effects were found within large-, medium- and small-sized DRG neurons. There was no significant difference in the somal diameter (A) and dorsal root conduction velocity (B) among different groups. Neurons infected with AdKir showed a significantly hyperpolarized resting potential (C) and lower input resistance (D) in comparison to those infected with AdEGI regardless of the presence or absence of CCD, which did not affect these two parameters. E: CCD surgery produced a significant reduction of rheobase in AdEGI-infected DRG neurons, but the effect was reversed by AdKir infection. F: Expression of Kir current (indicated by green fluorescence) also inhibited the spontaneous activity (SA) in CCD neurons. However, SA was still found in some neurons that did not express GFP in the same DRG. Inset in F: Reflected light (REF) and fluorescent (GFP) microscopic image showing the presence of viral-transferred GFP in the DRG neurons. Scale bar: 20 μm. *: P < 0.05 vs. AdEGI+CCD; †: P < 0.05 vs. AdEGI.

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Molecular Pain

ISSN: 1744-8069

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