Figure 3
From: Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice
Mechanical withdrawal threshold responses of double transgenic and WT mice after SNI model of neuropathic pain. Baseline (BL) recordings were taken before SNI. After surgery, the animals received no dox for 14 days, then dox for 7 days followed by a further 14 days with no dox. Pre-surgery thresholds were not significantly different between genotypes. The WT group developed robust allodynia and this was not affected by the administration of dox. Double transgenic mice developed significantly less allodynia than WT controls between days 3 and 14 of the first "off dox" period. No significant difference between the genotypes was observed from day 2 to 7 of the "on dox" period but a significant difference was again observed by day 7 of the second "off dox" period (2-way ANOVA. * denotes P < 0.05, ** denotes P < 0.01 and *** denotes P < 0.001).