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Figure 4 | Molecular Pain

Figure 4

From: Behavioral and anatomical characterization of the bilateral sciatic nerve chronic constriction (bCCI) injury: correlation of anatomic changes and responses to cold stimuli

Figure 4

Enhanced nocifensive responses to acetone application. (A) Acetone was applied to each separately hindpaw separately (5 trials per side) and results scored as % response. Higher percentage indicates development of cold hyper-reflexia. bCCI rats demonstrated significantly enhanced responsiveness (p < 0.001; F = 2442.5; df = 1; two-way ANOVA) for up to 43 days, which did not return to baseline. Each data point is group mean +/- SEM. (B) Acetone in a subgroup of 4 rats revealed that cold hyperalgesia persisted for up to 80 days.

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