Figure 4From: Behavioral and anatomical characterization of the bilateral sciatic nerve chronic constriction (bCCI) injury: correlation of anatomic changes and responses to cold stimuli Enhanced nocifensive responses to acetone application. (A) Acetone was applied to each separately hindpaw separately (5 trials per side) and results scored as % response. Higher percentage indicates development of cold hyper-reflexia. bCCI rats demonstrated significantly enhanced responsiveness (p < 0.001; F = 2442.5; df = 1; two-way ANOVA) for up to 43 days, which did not return to baseline. Each data point is group mean +/- SEM. (B) Acetone in a subgroup of 4 rats revealed that cold hyperalgesia persisted for up to 80 days.Back to article page