Hindpaw withdrawal responses to plantar probing with von Frey filament. Pressure was applied to each hindpaw with electronic von Frey filament. Applied force at the moment of paw withdrawal was determined. Rats were pre-tested to acclimatize to testing protocol. Statistically significant increased reflex withdrawal to mechanical stimuli returned to baseline at day 23 (p < 0.001; F = 801.17; df = 1; two-way ANOVA).