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Figure 1 | Molecular Pain

Figure 1

From: Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn

Figure 1

μ-Opioids presynaptically inhibit basal glutamatergic transmission in superficial dorsal horn neurons. (a) Time plot of miniature EPSC (mEPSC) rate during superfusion of deltorphin-II (Delt, 300 nM), DAMGO (3 μM) and naloxone (Nalx, 1 μM). (b) Averaged traces and (c) raw current traces of mEPSCs prior to (Pre), and during deltorphin-II, DAMGO and naloxone. Cumulative probability distribution plots of mEPSC (d) inter-event interval and (e) amplitude for the epochs averaged in (b) (number of events = 635, 640, 327 for control, deltorphin-II and DAMGO, respectively, over 80 s intervals). (a) - (e) are taken from one neuron.

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Molecular Pain

ISSN: 1744-8069

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