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Figure 2 | Molecular Pain

Figure 2

From: Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn

Figure 2

Effect of opioids on basal, and menthol and icilin enhanced miniature EPSCs. (a) Bar chart showing the percentage inhibition of miniature EPSC (mEPSC) rate produced by DAMGO (3 μM), deltorphin-II (Delt, 300 nM) and U69593 (300 nM), expressed as a percentage of the pre-opioid level and averaged across all neurons tested. (b) Bar chart showing the percentage of neurons in which DAMGO, deltorphin-II and U69593 produced a reduction in mEPSC rate of greater than 15%. Data in (a) and (b) are shown for neurons in which opioids were superfused alone, or in the additional presence of menthol (400 μM), or icilin (100 μM). The number in the bars represent (a) the total number of neurons tested and (b) the number of neurons which responded to each opioid.

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Molecular Pain

ISSN: 1744-8069

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