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Figure 6 | Molecular Pain

Figure 6

From: Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice

Figure 6

Effects of devazepide on ephrin B1 and Eph B1 receptor gene expression and IL-1β production. B16/BL6 cells were injected into the plantar region of the right hind paw of C57BL/6 mice, and devazepide (Deva, 10 mg/kg) was then administered orally once a day from day 7 after transplantation. A final oral administration of devazepide was given to mice prior to the collection of L4-5 DRG and right hind paw samples on day 14 after transplantation. Gene expression analyses for ephrin B1 (A) and the Eph B1 receptor (B) in DRGs were performed by quantitative real-time RT-PCR. Data represent fold changes versus the mean for normal mice. Columns represent the mean ± S.E. (n = 12). ##, p < 0.01, versus normal (t-test); **, p < 0.01, versus vehicle (t-test). C. Right hind paw samples were subjected to the extraction of IL-1β which was then measured by ELISA. The data are reported as the mean ± S.E. (n = 12). ###, p < 0.001, normal versus vehicle (Wilcoxon test); p = 0.08 (devazepide treatment), vehicle versus devazepide (Wilcoxon test).

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Molecular Pain

ISSN: 1744-8069

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