Figure 8
From: Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice
Cell proliferation in ION region in the trigeminal ganglion at day 8 after pIONL. (A) Data came from ION region in TG (the area shown in red box). (B, C, F), pIONL induced marked upregulation of BrdU positive cells in the ipsilateral side of ION region in WT mice. (B-H), in KOR-/- and norBNI pre-treated mice, the number of BrdU positive cells significantly increased compared to WT pIONL mice. (I-N) Different cellular markers (GFAP for satellite cells, S100beta for Schwann cells, CD11b for macrophage) were used to identify the phenotypes of dividing cells. Only rare cells were double labeled for BrdU and GFAP or S100beta. The majority of BrdU positive cells were CD11b positive macrophage. (*p < 0.001). Scale bars: A, 250 μm, C-H, 50 μm, I-N, 30 μm.