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Figure 4 | Molecular Pain

Figure 4

From: Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCϵ pathway in dorsal root ganglion neurons

Figure 4

Potentiation of TRPV1 current by LPA in DRG neurons of bone cancer rats. A and B: Typical whole-cell patch recordings of DRG neurons in bone cancer and sham rats, respectively. No current was evoked by a low concentration of capsaicin (0.5 nM) in DRG neurons (the upper trace of A and B). A: In a bone cancer rat, capsaicin (0.5 nM) evoked a visible inward current (the lower trace) 3 min after LPA (0.01 μM) perfusion. B: In a sham-operated rat, no effect of LPA on application of capsaicin was observed.

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Molecular Pain

ISSN: 1744-8069

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