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Figure 5 | Molecular Pain

Figure 5

From: PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects

Figure 5

Time-course of the antinociceptive effect of peptide PK20 alone and PK20 after a naltrexone injection. A. analgesic effect of chimeric compound PK20 injected intrathecally at a dose of 0.02 nmol/rat; B. analgesic effect of PK20 (0.02 nmol), injected 10 min after a naltrexone (10 μg/rat) injection. % MPE ± SEM of six animals per group. *p < 0.05; **p < 0.001 as compared to rats treated with PK20 (0.02 nmol/rat) alone.

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