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Figure 2 | Molecular Pain

Figure 2

From: Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1

Figure 2

Increased excitatory and decreased inhibitory transmission in CeLC neurons in a model of arthritic pain. (A) Input-output (I/O) functions of monosynaptic EPSCs (recorded at -70 mV) increased significantly (P < 0.0001, two-way ANOVA, see Results) in slices from arthritis rats (n = 12 neurons) compared with control slices from normal rats (n = 11 neurons). Traces show EPSCs evoked with stimulus intensities of 0.3, 0.6 and 0.9 mA in one CeLC neuron from a normal rat and in another CeLC neuron from an arthritic rat. Scale bars, 50 pA, 10 ms. (B) I/O function of IPSCs (recorded at 0 mV) decreased significantly (P < 0.0001, two-way ANOVA, see Results) in slices from arthritic rats (n = 12 neurons) compared with slices from normal rats (n = 11 neurons). Individual traces show IPSCs evoked with stimulation intensities of 0.3, 0.6 and 0.9 mA. Scale bars, 50 pA, 10 ms. (C) The ratio of EPSCs and IPSCs evoked with a stimulation intensity of 1 mA increased significantly in slices from arthritic rats (n = 12 neurons) compared to controls (n = 11 neurons). *** P < 0.001, unpaired t-test. (A-C) Symbols and error bars represent means ± SE.

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Molecular Pain

ISSN: 1744-8069

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