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Figure 3 | Molecular Pain

Figure 3

From: Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1

Figure 3

Inhibitory transmission onto CeLC neurons is driven by non-NMDA receptors. (A) A non-NMDA receptor antagonist (NBQX, 10 μM) decreased input-output (I/O) functions of IPSCs (recorded at 0 mV) in slices from normal rats significantly (n = 5 neurons, P < 0.0001, two-way ANOVA; see Results). Traces show IPSCs evoked in one CeLC neuron before (Predrug) and during NBQX. Stimulus intensity, 0.9 mA; scale bars, 50 pA, 10 ms. (B) NBQX also decreased I/O function of IPSCs (recorded at 0 mV) in slices from arthritic rats (n = 5 neurons) significantly (n = 5 neurons, P < 0.0001, two-way ANOVA; see Results). Individual traces show IPSCs evoked in one CeLC neuron before (Predrug) and during NBQX. Stimulus intensity, 0.9 mA; scale bars, 50 pA, 10 ms. (C) The effect of NBQX normalized to predrug values (set to 1.0) was not significantly different between slices from arthritic rats and normal controls (P > 0.05, unpaired t-test). (A-C) Symbols and error bars represent means ± SE.

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Molecular Pain

ISSN: 1744-8069

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