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Figure 6 | Molecular Pain

Figure 6

From: Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1

Figure 6

Blockade of mGluR5 inhibits excitatory and inhibitory transmission under normal conditions and in arthritis. (A) A selective mGluR5 antagonist (MTEP, 1 μM) decreased I/O functions of excitatory transmission in slices from normal rats significantly (n = 5 neurons, P < 0.01, two-way ANOVA; see Results). (B) MTEP inhibited EPSCs in slices from arthritic rats significantly (n = 5 neurons, P < 0.0001, two-way ANOVA; see Results). (C) Normalized effects (to predrug; set to 1.0) of MTEP on EPSCs were not significantly between arthritis and normal conditions (P > 0.05, unpaired t-test). (D) MTEP decreased I/O functions of inhibitory synaptic transmission in slices from normal animals (n = 5 neurons, P < 0.0001, two-way ANOVA; see Results). (E) MTEP decreased IPSCs in slices from arthritic rats significantly (n = 5 neurons, P < 0.01, two-way ANOVA; see Results). (F) Normalized effects (to predrug; set to 1.0) of MTEP on IPSCs were not significantly different between normal and arthritis conditions (P > 0.05, unpaired t-test). (A-F) Symbols and error bars represent means ± SE.

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Molecular Pain

ISSN: 1744-8069

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