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Figure 7 | Molecular Pain

Figure 7

From: Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse

Figure 7

AvCreERT2 expression or tamoxifen (10 mg) treatment does not affect inflammatory nociceptive responses. A - Behavioural responses of AvCreERT2 and littermate mice to inflammatory pain tests Aa) Pain behaviour of AvCreERT2 (N = 6) & littermate (N = 6) mice after intraplantar injection of 20 μl of 5% formalin. Ab) Time spent licking/biting the injected hindpaw in phase I (1-10 min) and phase II (10-60 min) (AvCreERT2 N = 6, littermate N = 6), Ac) Mechanical allodynia following intraplantar injection of 20 μl of CFA (AvCreERT2 N = 7, littermate N = 6), Ad) Thermal hyperalgesia after intraplantar injection of 20 μl of CFA (AvCreERT2 N = 7, littermate N = 6). No significant difference was found (Two-way repeated measures ANOVA). Data are expressed as mean ± SEM. B - Behavioural responses of C57BL/6 mice injected with a five-day course of tamoxifen (2 mg/0.2 ml per day), or vehicle (0.2 ml per day) to inflammatory pain tests. Ba) Pain behavior of tamoxifen-treated (N = 6) & vehicle-treated (N = 6) mice after intraplantar injection of 20 μl of 5% formalin. Bb) Time spent licking/biting the injected hindpaw in phase I (1-10 min) and phase II (10 -60 min) (tamoxifen N = 6, vehicle N = 6), Bc) Mechanical allodynia following intraplantar injection of 20 μl of CFA (tamoxifen N = 6, vehicle N = 6), Bd) Thermal hyperalgesia after intraplantar injection of 20 μl of CFA (tamoxifen N = 6, vehicle N = 6). Animals were examined 7 days following tamoxifen/vehicle treatment. No significant differences were found (Two-way repeated measures ANOVA). Data are expressed as mean ± SEM.

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