Figure 4
From: Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C
Inhibition of α,β-meATP-evoked action potentials by the PKC blocker calphostin C in neuropathic DRG neurons. (A) Typical recordings obtained from current-clamp experiments in neuropathic DRG neurons at resting membrane potential show action potentials generated in response to 1 and 10 μM α,β-meATP (upper panel), and their inhibition in the presence of 100 nM calphostin C (lower panel). (B) Percentage of DRG neurons that generated action potentials in response to α,β-meATP, in absence and presence of 100 nM calphostin C (N = 7-13).