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Figure 6 | Molecular Pain

Figure 6

From: 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice

Figure 6

5-HIAA measurements by HPLC from both genotypes on day 2 and 7 after CFA or saline in sciatic nerve (a) and spinal cord (b) of wild-type (black bars) and 5-HTT-/- mice (open bars). In control groups, there was no significant difference in 5-HIAA in sciatic nerve and spinal cord investigated between two genotypes. Two days and 7 days after CFA in 5-HTT-/- mice, the 5-HIAA was significantly reduced in sciatic nerve and spinal cord with the exception of 5-HIAA in sciatic nerve on day 2. (*p < 0.05 compared with wild-type mice after CFA). In sciatic nerve of 5-HTT-/- mice, 5-HIAA could not be detected on day 7 after CFA, and it was increased in both genotypes on day 2 after CFA. 5-HIAA was further reduced in spinal cord in both genotypes on day 2 after CFA, and in 5-HTT-/- mice on day 7 after CFA (# p < 0.05 compared with saline-treated groups respectively). On day 3 after i.pl. CFA or NS, 5-HIAA concentrations in sciatic nerve (c) and spinal cord (d) were decreased in wild-type mice pretreated with p-CPA (*p < 0.05 compared with pretreatment of NS group). n = 4~6 for each group.

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Molecular Pain

ISSN: 1744-8069

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