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Figure 1 | Molecular Pain

Figure 1

From: (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice

Figure 1

Thermal antinociceptive effects of (-)-pentazocine in wildtype, heterozygous, and homozygous MOP-KO mice. (-)-Pentazocine-induced alterations of %MPE in the hot-plate (A, B) and tail-flick (C, D) tests in wildtype (+/+; [A, C] closed circles, n = 12; [B, D] gray closed circles [male, n = 6], open circles [female, n = 6]), heterozygous (+/-; [A, C] closed triangles, n = 12; [B, D] gray closed triangles [male, n = 7], open triangles [female, n = 5]), and homozygous (-/-; [A, C] closed squares, n = 13; [B, D] gray closed squares [male, n = 8], open squares [female, n = 5]) MOP-KO mice under a cumulative dose-response paradigm. (A, C) Combined data of male and female mice. # p < 0.05, significantly different from wildtype mice. (B, D) # p < 0.05, significantly different from male wildtype mice; *p < 0.05, significantly different from female wildtype mice. Data are expressed as mean ± SEM.

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Molecular Pain

ISSN: 1744-8069

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