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Figure 2 | Molecular Pain

Figure 2

From: Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats

Figure 2

K ATP opener reverses BK-induced hyperexcitability of DRG neurons. Current clamp recordings from rat DRG neurons; action potentials were elicited by 300 pA current injection for 500 ms period. Either one (A) or multiple (B) action potentials were induced by the depolarization, and the firing frequency was increased by BK (200 nM), which was reversed by pinacidil (Pin, 10 μM). (C) Numbers of action potentials/s (AP) in the absence or presence of BK, pinacidil and BK plus pinacidil. n = 35, **p < 0.01. (D) Resting membrane potentials (RMP) of DRG neurons and the effects of BK, pinacidil and BK plus pinacidil. n = 35, *p < 0.05.

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Molecular Pain

ISSN: 1744-8069

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