Figure 1

Temperature preference and heat-evoked acute nociceptive behavior of TRPV3 knockout mice on the C57BL6 background. (A) Thermal preference behavior of freely moving wild-type (black solid line, n = 12) and TRPV3 knockout (KO, red dashed line, n = 12) mice on a floor temperature gradient of 0.8°C to 48.8°C over 120 minutes. Percent of time spent (mean ± SEM) within the indicated 2°C bins was monitored during the indicated time periods. (B) Thermal preference behavior of freely moving wild-type (filled black squares, n = 10-12) and TRPV3 knockout (KO, open red circles, n = 10-12) mice in a two-temperature selection task. Percent of time spent (mean ± SEM) at the indicated floor temperature was monitored for 5 min intervals over 60 min. Floor temperature choices were 33°C vs 37°C (left), 35°C vs. 24°C (middle), and 34°C vs. 28°C (right). (C) Heat-evoked acute nociceptive behavior of wild-type (filled bars) and TRPV3 KO (open bars) mice. Latency to response was measured in the tail immersion (left, n = 13) and hot plate (middle, n = 10) assays at the indicated temperatures. Latency to response in the radiant paw heating assay (n = 13-14) was measured during stimulation at a fixed lamp intensity. Data represent mean ± SEM.