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Figure 2 | Molecular Pain

Figure 2

From: Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord

Figure 2

ERK phosphorylation following MIA injection. ERK1/2 phosphorylation was increased in both ipsilateral and contralateral dorsal horn spinal cord at 2 and 3 wk following MIA compared to naïve control rats, (A). Phospho-ERK1/2 immunoreactivity (black stained cells) was observed in the upper lamina (hatched box) of the dorsal horn (B) that reached maximal levels at 3-wks as compared to naive (non-pain) controls. An overall ANOVA showed a significant main treatment effect (F = 2.965, p = 0.0134). All data are represented as mean values (± S.E.M) of the percent of ipsilateral naïve control rats; * p < 0.05, ** p < 0.01, vs. naïve controls (Fisher's PLSD post hoc analysis); n = 6/group.

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Molecular Pain

ISSN: 1744-8069

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