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Figure 5 | Molecular Pain

Figure 5

From: Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord

Figure 5

Spinal glial activation in MIA-OA rats. Microglia, but not astrocyte, activation was observed in the ipsilateral dorsal horn 3-wk following MIA injection (Figure 5). In 3-wk MIA-treated rats, a significant increase in ipsilateral, but not contralateral, microglia expression was observed in the spinal dorsal horn, as determined by OX-42 (CD11b) immunoassaying, when compared to naive controls (A). In contrast, 3-wk MIA rats exhibited no differences in ipsilateral or contralateral astrocyte expression, as determined by GFAP immunoassaying, when compared to naive controls (B). All data are represented as mean values (± S.E.M) of the percent of ipsilateral naïve control rats; * p < 0.05 vs. naïve controls (Fisher's PLSD post hoc analysis); n = 6/group.

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Molecular Pain

ISSN: 1744-8069

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