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Figure 8 | Molecular Pain

Figure 8

From: Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse

Figure 8

Distribution of nociceptive markers in cells with and without sympathetic contacts. DRG sections were stained for the indicated marker (red) and for TH (green) on POD3. Left: examples of dual staining from fixed DRG sections. Arrows indicate examples of cells expressing the indicated marker along with sympathetic basket formations or nearby fibers. (Scale bar = 25 μm). Right: summary of percentage of cells in each class expressing the indicated marker. ***, percentage of cells with basket/ring formations or with nearby sympathetic fibers expressing each marker was significantly higher (p < 0.001) than the percentage observed in cells lacking sympathetic contacts. #, significant difference (p < 0.05) between the basket cells and cells with nearby fibers (Chi-square test). The dotted lines indicating the overall percentage of cells expressing each marker on POD 3 are close to the values for cells with no sympathetic fibers because only 18 - 22% of cells have any sort of sympathetic contact. Data are combined from 3 separate animals for each marker; findings were similar within each individual group. N values for each group are given in Table 1.

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Molecular Pain

ISSN: 1744-8069

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