Antinociceptive effects of SN50, an NF-κB inhibitor. Effects of SN50 on mechanical allodynia produced by mal-positioned dental implants in rats (A). On POD 3, SN50 did not produce anti-nociceptive effects (upper panel). The intracisternal administration of SN50 (0.2 or 2 ng) inhibits mechanical allodynia on the ipsilateral (left) and contralateral side (right) on POD 21 in a dose-dependent manner. These anti-allodynic responses persist for six hours and are recovered within 24 hours. The intracisternal administration of SN50 (2 ng) attenuates NF-κB activation on POD 21 following inferior alveolar nerve injury as compared to the vehicle group (B). Western blotting analysis showed decreases in p-NF-κB expression following injection of SN50 as compared to the vehicle treatment (C). *P < 0.001, vehicle- vs. SN50-treated group. Scale bars, 50 μm.