Figure 2
From: Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas
Expression of Nav and Kv7.2 channels in nodes of proximal neuromas. A and B show isolated teased fibers from nerve-end neuromas immunostained for Myelin P2 and Pan Nav (A) or Kv7.2 (B). In this proximal zone of the neuroma, the structure of the fibers was conserved and individual nodes/paranodes were still identifiable. C 1 shows a high magnification image of three nodal zones stained with Pan Nav and Myelin P2; C 2 shows the immunostaining intensity profile corresponding to the nodal zone marked with an asterisk in C 1 . D 1 shows a high magnification image of a nodal zone stained for Kv7.2 and myelin with its corresponding profile of immunostaining intensity (D 2 ). Scale bars: for A and B, 10 μm (shown in B); for C 1 and D 1 , 5 μm (shown in D).