Figure 4
From: Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas
Increase in Nav and Kv7.2 co-expression after axotomy. A shows low magnification fields containing nodal accumulations of Nav (A 1 ) and Kv7.2 (A 2 ) channels in control nerve. A 3 shows a merge of A1 and A2 showing co-staining of some nodes (marked by arrows). B and C follow the same scheme as A but fields were obtained from the proximal end (B) or the distal end of the neuroma (C). Note the large proportion of co-staining in neuromatose fibers. D 1 shows a larger scale picture of a long nodal formation which corresponds to the area in the red square of B 3 . D 2 shows the immunostaining intensity profile corresponding to the nodal zone marked with an asterisk in D 1 . Scale bars: for A and B 10 μm (shown in B 3 ); for C, 10 μm (shown in C 3 ); for D 2 , 5 μm.