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Figure 2 | Molecular Pain

Figure 2

From: mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

Figure 2

The formalin test in mGlu2-/- and mGlu3-/- mice. A, Enhanced pain behavior in mGlu2-/- mice after formalin injection. The first phase (0 - 10 min) of pain behavior (defined as duration of licking responses) did not differ between mGlu2+/+ mice and mGlu2-/- mice after formalin injection, but the second phase (10 - 50 min) was significantly enhanced in mGlu2-/- mice. The acute injection of LY379268 (3 mg/kg i.p.) 30 minutes before formalin injection significantly reduced both phases in mGlu2+/+ mice but not in mGlu2-/- mice. B, mGlu3-/- mice did not significantly differ from littermate mGlu3+/+ mice in either of the two phases of the formalin test. The acute injection of LY379268 (3 mg/kg i.p.) 30 minutes before formalin injection elicited a significant reduction of both phases in mGlu3+/+ mice and in mGlu3-/- mice. Data represent the mean ± S.E.M. of 8 to 12 mice per group. *p < 0.05 versus the respective vehicle group, ° p < 0.001 vs wild-type mice (two-way ANOVA)

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Molecular Pain

ISSN: 1744-8069

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