Table 3 Lack of anti-hyperalgesic effects by repeated systemic administration of antidepressants

Control-vehicle

(i.v.)

8

9.51 ± 0.22

9.80 ± 0.18

10.00 ± 0.29

9.57 ± 0.30

ICS-vehicle

(i.v.)

8

9.67 ± 0.23

5.78 ± 0.36

6.02 ± 0.12

6.36 ± 0.21

ICS- amitriptyline

(3 mg/kg, i.v.)

4

9.55 ± 0.42

5.85 ± 0.37

5.79 ± 0.36

6.72 ± 0.35

ICS-mianserin

(10 mg/kg, i.v.)

4

9.77 ± 0.34

5.14 ± 0.56

5.98 ± 0.39

6.66 ± 0.41

ICS- paroxetine

(1 mg/kg, i.v.)

4

9.34 ± 0.36

5.29 ± 0.34

6.89 ± 0.30

6.96 ± 0.65

ICS- milnacipran

(10 mg/kg, i.v.)

4

9.75 ± 0.47

6.25 ± 0.25

6.71 ± 0.21

7.54 ± 0.53