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Figure 5 | Molecular Pain

Figure 5

From: Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain

Figure 5

AMPK activators suppress translation in sensory neurons and the injured PNS. Treatment of mouse sensory neurons cultured in the presence of NGF (50 ng/ml) with A) Metformin (2 and 20 mM) or B) A769662 (50 and 500 μM) results in decreased binding of eIF4G and increased 4EBP binding to the m7GTP-cojugated sepharose beads in a dose-dependent manner consistent with a decrease in eIF4F complex formation. C) Metformin treatment of rats with SNL restores nascent protein synthesis in injured nerves to levels observed in uninjured nerves. N = 6 per group. *p < 0.05, ** p < 0.01.

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Molecular Pain

ISSN: 1744-8069

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