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Figure 3 | Molecular Pain

Figure 3

From: EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat

Figure 3

Tail flick latencies after intra-VL PAG microinjections of vehicle (0.05% DMSO in ACSF), ONO-DI-004 (0.001, 0.01 and 0.1 pg) alone, or ONO-DI-004 (0.1 pg) in combination with L355677 (0.1 pg) (A) or L335677 (0.1, 1 and 10 pg) (B). Tail flick latencies were also measured in sham and SNI rats. In particular, C shows the effect of intra-VL PAG microinjections of vehicle (0.05% DMSO in ACSF) or ONO-DI-004 (0.1 pg) and D indicates the effects of vehicle or L335677 (10 pg) in sham and SNI rats 7 days after SNI surgery. Each point represents the mean ± S.E.M of 12-14 rats per group. * indicates a statistically significant difference vs vehicle and° vs ONO-DI-004 (0.1 pg) in A and B. * indicates a statistically significant difference vs sham/vehicle and° vs SNI/vehicle in C and D. P values < 0.05 were considered statistically significant.

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