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Figure 3 | Molecular Pain

Figure 3

From: The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

Figure 3

Effect of the σ 1 -receptor agonist (+)-pentazocine [(+)PTZ, 10 mg/kg, s.c] on the Phe-Phe amide (2 pmol, i.t.)-induced prolongation of the tail-flick latency in non-diabetic and diabetic mice. (+)PTZ was administered subcutaneously 30 min prior to the administration of Phe-Phe amide. Each column represents the mean with S.E.M. for 10 mice. *P < 0.05, ***P < 0.001 vs. respective before-treatment group; #P < 0.05, ###P < 0.001 vs. vehicle-pretreated group (Bonferroni test).

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Molecular Pain

ISSN: 1744-8069

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