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Figure 3 | Molecular Pain

Figure 3

From: Stimulation of peripheral Kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway

Figure 3

PI3Ks mediates the peripheral antinociceptive action of KOR agonists. (A-B) Mechanical hyperalgesia in rats was induced by an ipl. injection of PGE2 (100 ng/paw). The antinociceptive effect of U50488 (10 μg/paw, 2 h after PGE2 injection) after PGE2-induced hyperalgesia was prevented by a pretreatment (30 min) with non-selective inhibitors of PI3Ks: wortmannin (3 μg/paw) or LY294002 (10 μg/paw). Data are expressed as the mean ± S.E.M. of 5-6 animals per group. * Indicates statistical significance compared to the vehicle group. # Indicates statistical significance compared to the U50488 treated group. P < 0.05, one-way ANOVA, followed by the Bonferroni correction.

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Molecular Pain

ISSN: 1744-8069

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