Figure 1
From: Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation
Systemic administration of minocycline inhibits acetic acid-induced abdominal pain. (A) Time course of 1% acetic acid (250 μl, i.p.)-induced visceral pain behavior (mean ± SE). Number of abdominal constrictions after acetic acid administration was significantly inhibited by pretreatment of minocycline in a dose dependent manner. (B) Total abdominal constrictions were attenuated by minocycline in a dose-related fashion following i.p. injection of acetic acid. Values are expressed mean ± SEM. *, P < 0.01 versus control group (saline-pretreated and acetic acid-treated animals (ANOVA test with a Fisher's post hoc test)