Figure 5
From: Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation
Administration of PD-98059 inhibits acetic acid-induced abdominal pain. (A) Time course of 1% acetic acid (250 μl, i.p.)-induced visceral pain behavior (mean ± SE). Number of abdominal constrictions (writhes) after acetic acid administration was significantly inhibited by intrathecal pretreatment of PD-98059 in a dose dependent manner. (B) Total abdominal constrictions were remarkably attenuated by intrathecal administration of PD-98059 in a dose-related fashion following i.p. injection of acetic acid. *, P < 0.01 versus control group (vehicle-pretreated and acetic acid-treated animals). (ANOVA test with a Fisher's post hoc test)