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Figure 3 | Molecular Pain

Figure 3

From: Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root

Figure 3

The acute effects of daily treatments with progesterone (8 or 16 mg/kg/day) on mechanical allodynia in rats microinjected with LPA into the trigeminal nerve root. Daily treatment with a low dose of progesterone (8 mg/kg/day) did not produce anti-allodynic effects. However, the administration of 16 mg of progesterone on postoperative days 3, 4, and 5 produced significant anti-allodynic effects. * P < 0.05, vehicle- vs. progesterone-treated group.

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