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Figure 2 | Molecular Pain

Figure 2

From: Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K2P) and voltage-gated (Kv1.1 and Kv1.2) potassium channels

Figure 2

Partial inhibitory effect of IQ on K v 1.1 and K v 1.2 activity. A, C Effect of different concentrations of IQ on Kv1.1 (A) and Kv1.2 (C) currents induced by a voltage step. Protocol of voltage step shown below the traces. B, D. Average % of remaining currents of Kv1.1 (B) and Kv1.2 (D) during IQ (1, 10, 100 and 500 μM) application. Concentration-response relationship was obtained by fitting with logistic function. IC50 of IQ on Kv1.1 and Kv1.2 is 39.2 μM and 21.32 μM, respectively. Error bars indicate S.E.M.

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Molecular Pain

ISSN: 1744-8069

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