Figure 1
From: Sodium channels and mammalian sensory mechanotransduction
Acute pain thresholds are normal in β and γ ENaC KO mice. a) The Randall-Selitto test between βENaCflox/flox and Nav1.8-Cre/βENaCflox/floxmice does not show any difference in behavior (t test, p = 0.6, n = 8 and 9 respectively). b, c and d) comparison of βENaCflox/flox and Advillin-Cre/βENaCflox/flox mice in the Von Frey test (t test, p = 0.64, n = 6 and 7 respectively), the Hargreaves test (t test, p = 0.6, n = 8 and 7 respectively) and the rotarod test (t test, p = 0.88, n = 4 and 4 respectively). e) Randall-Selitto test between γENaCflox/flox and Nav1.8-Cre/γENaCflox/flox mice (t test, p = 0.57, n = 10 and 10 respectively). f,g and h) comparison of γENaCflox/flox and Advillin-Cre/γENaCflox/flox mice in the Von Frey test (t test, p = 0.13, n = 11 and 13 respectively), the Hargreaves test (t test, p = 0.26, n = 13 and 12 respectively) and the rotarod test (t test, p = 0.56, n = 4 and 6 respectively).