Figure 1

Effects of KN-93 and KN-92 on oxaliplatin-induced mechanical allodynia in the von Frey test. Rats were treated with oxaliplatin (4 mg/kg, i.p.) twice a week for 4 weeks (days 1, 2, 8, 9, 15, 16, 22 and 23). We confirmed the incidence of mechanical allodynia on day 24. We carried out the drug evaluation on the next day. KN-93 (10-50 nmol) or KN-92 (50 nmol) was administered intrathecally. The von Frey test was performed immediately before (0 min) and at 30, 60, 90 and 120 min after administration. KN-93 (50 nmol) significantly reversed oxaliplatin-induced mechanical allodynia (A). On the other hand, KN-92 (50 nmol) had no effect on the mechanical allodynia (B).Values are expressed as the mean ± SEM. of 5-8 animals. **p < 0.01 compared with vehicle (Student's t-test). †p < 0.05 compared with oxaliplatin alone (one-way ANOVA followed by Tukey-Kramer post-hoc test).