Figure 4

Effect of trifluoperazine on oxaliplatin-induced mechanical allodynia in the von Frey test. Rats were treated with oxaliplatin (4 mg/kg, i.p.) twice a week for 4 weeks (days 1, 2, 8, 9, 15, 16, 22 and 23). We confirmed the incidence of mechanical allodynia on day 24. We carried out the drug evaluation on the next day. Trifluoperazine (0.05-0.3 mg/kg) was administered orally. The von Frey test was performed immediately before (0 min) and at 30, 120 and 240 min after administration of trifluoperazine. Trifluoperazine (0.1 and 0.3 mg/kg) significantly reversed oxaliplatin-induced mechanical allodynia. Values are expressed as the mean ± SEM. of 8 animals. **p < 0.01 compared with vehicle, †p < 0.05, ††p < 0.01 compared with oxaliplatin alone (one-way ANOVA followed by Tukey-Kramer post-hoc test).