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Figure 2 | Molecular Pain

Figure 2

From: Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study

Figure 2

Different groupings for brain activity for spontaneous fluctuations of pain of CBP calculated for brain scans collected at baseline. Coordinates x = 8, y = 56, z = 20 for A-D (top row are sagittal, middle horizontal, and bottom coronal slices; middle and bottom rows: left side is left hemisphere). A. Whole-group average brain activity for rating spontaneous pain of CBP patients (n = 30 subjects). Brain activity was limited to medial prefrontal cortex (BA 9) and the genual anterior cingulate cortex (BA 32). B. Contrast between activity for rating spontaneous pain of CBP and rating length of a bar varying in time (control for visual, motor, and task demands; paired t-statistic n = 30 subjects) identifies the same brain activity as in A. C and D. Brain activity was similar between placebo (C) and lidocaine (D) treated groups for spontaneous pain of CBP at baseline (n = 15 subjects per group), and closely matched whole-group activity shown in activity and contrast maps were generated using random-effects statistics with z score ≫ 2.3 and cluster threshold p ≪ 0.01, corrected for multiple comparisons.

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Molecular Pain

ISSN: 1744-8069

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