Figure 3
From: Retracted: Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states
Expression of CACNA2D1 mRNA. Expression of CACNA2D1 mRNA was upregulated in both dorsal spinal cord (A) and lumbar DRGs (B) in the presence of either diabetic peripheral neuropathy (DPN) or spinal nerve ligation (SNL). Dorsal horn mRNA expression was unchanged by presence of high dose pregabalin (2.04 mg/kg/d) provided either through intrathecal or intranasal delivery when compared to saline delivery (A). There was no impact of pregabalin delivered in any manner upon mRNA expression in lumbar DRGs when compared to saline delivery, although the presence of spinal nerve ligation or diabetic peripheral neuropathy was associated with elevated CACNA2D1 mRNA expression when compared to control rat specimens (B), indicated by the * above the Control rat data (non-matched ANOVA tests, F-values range between 0.42-1.00 for indicated groups and time points, n ≥ 3, * p < 0.0125) [n = 6-8 specimens for each cohort].