Figure 2

Experimental pain paradigm and functional connectivity results. The schematic illustration (A) represents the experimental pressure pain paradigm used during fMRI scanning. Calibrated painful pressures (long lines), representing 50 mm VAS, and non-painful pressures (short lines) were randomly delivered to the thumbnail during 2 adjacent 8 minute runs with 20 painful and 10 non-painful stimuli in each run. Functional connectivity results for the rACC seed (B) revealed incraesed connectivity to the amygdala (peak coordinate x = −14, y = 0, = − 16) and a cluster encompassing the brainstem/PAG/hippocampus (peak coordinate x = 12, y = 24, z = −12) in healthy controls, comapred to FM patients. Functional connectivity results for the thalmaus seed (C) revealed increased connectivity to the OBFC (peak coordinate x = −34, y = 50, z = −18) in healthy controls, compared to FM patients. All anatomical locations are given in Montreal Neurological Institute coordinates (MNI).